반응 #1905851

반응 방정식

5′-Amino-2′,5′-dideoxyuridine

2-chlorotrityl chloride

2-chlorotrityl chloride

→

title compound

수율 16.2%

5′-[(2-chlorotrityl)amino]2′,5′-dideoxyuridine

수율 16.2%

용매

pyridine

반응 조건

후처리

1. 1
   기타the reaction was quenched with MeOH (2 mL)
2. 2
   농축The reaction mixture was concentrated in vacuo
3. 3
   기타purified by flash column chromatography
4. 4
   세척eluted with a gradient of 0→5% CH3OH in CHCl3

실험 절차

5′-Amino-2′,5′-dideoxyuridine (0.237 g, 1.04 mmol) was reacted with 2-chlorotrityl chloride (0.415 g, 1.33 mmol) in dry pyridine (5 mL) at 40° C. for 24 h. A second portion of 2-chlorotrityl chloride (0.198 g, 0.63 mmol) was added. After a further 2 h stirring at 40° C., the reaction was quenched with MeOH (2 mL). The reaction mixture was concentrated in vacuo and purified by flash column chromatography using an ISOLUTE Si column eluted with a gradient of 0→5% CH3OH in CHCl3. The fractions with Rf=0.17 (10% CH3OH/CHCl3) yielded the title compound as a white solid (85 mg, 16%).

출처