반응 #1905484

ord-1a46e4332afe418f9db0b3c064aeb8b4

반응 방정식

CCOC(=O)c1nc(NC(=O)N(C2CCCCC2)C2CCCCC2)sc1SC#N
2-(3,3-dicyclohexyl-ureido)-5-thiocyanato-thiazole-4-carboxylic acid ethyl ester
CI
methyl iodide
CCOC(=O)c1nc(NC(=O)N(C2CCCCC2)C2CCCCC2)sc1SC
2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid ethyl ester
CSc1sc(NC(=O)N(C2CCCCC2)C2CCCCC2)nc1C(=O)O
title compound
CSc1sc(NC(=O)N(C2CCCCC2)C2CCCCC2)nc1C(=O)O
2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Hydrolysis

실험 절차

2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid ethyl ester was prepared as described in general procedure (H) using 2-(3,3-dicyclohexyl-ureido)-5-thiocyanato-thiazole-4-carboxylic acid ethyl ester and methyl iodide. Hydrolysis using general procedure (F) gave the title compound.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07598391B2uspto-grants-2009_10