반응 #1903

반응 방정식

4-bromo-3-methoxyphenol

benzyl bromide

potassium carbonate

→

4-benzyloxy-2-methoxybromobenzene

용매

acetone

반응 조건

후처리

1. 1
   기타The insoluble materials were removed by filtration
2. 2
   농축the filtrate was concentrated in vacuo
3. 3
   기타The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1)

실험 절차

A mixture of 4-bromo-3-methoxyphenol (21 g), benzyl bromide (13.5 ml), potassium carbonate (21.4 g) and acetone (200 ml) was stirred at room temperature for 24 h. The insoluble materials were removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1) to give 4-benzyloxy-2-methoxybromobenzene (25 g) as an oil.

출처