반응 #1902012

ord-b1eda868f3b0479caeb4f973fd2367f3

반응 방정식

CCCOc1ccccc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1
compound
CCCOc1ccccc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1
2-(2-Propoxyphenyl)-5-methyl-7-cyclopentyl-3H -imidazo[5,1-f][1,2,4]-triazin-4-one
O=[N+]([O-])O
nitric acid
→
CCCOc1ccc([N+](=O)[O-])cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1
5-Nitro-2-propoxyphenyl-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

반응물

CCCOc1ccccc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1
compound
CCCOc1ccccc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1
2-(2-Propoxyphenyl)-5-methyl-7-cyclopentyl-3H -imidazo[5,1-f][1,2,4]-triazin-4-one
O=[N+]([O-])O
nitric acid

시약

없음

용매

O=C(O)C(F)(F)F
trifluoroacetic acid

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타The product is purified by silica gel chromatography

실험 절차

Analogously to the procedure of example 41A, 10.0 g (28.4 mmol) of the compound from example 26A are nitrated in 160 ml of trifluoroacetic acid and 40 ml of 70% strength nitric acid. The product is purified by silica gel chromatography using toluene and ethyl acetate in a gradient system.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06878708B2uspto-grants-2005_04