반응 #1898866

반응 방정식

HCl

D-Phenylglycine

NaHCO3

Ethylchloroformate

→

(R)-2-(ethoxycarbonylamino)-2-phenylacetic acid

수율 82.0%

용매

THF

water

반응 조건

후처리

1. 1
   추출The aqueous layer was extracted with EtOAc
2. 2
   건조The organic layers were dried over MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated under reduced pressure

실험 절차

D-Phenylglycine (R) (85.2 mmol) was dissolved in anhydrous THF (260 mL) with NaHCO3 (256 mmol) in water (260 mL). Ethylchloroformate (0.235 mol) was added. After stirred at room temperature overnight, the reaction mixture was acidified to pH 3 with 1N HCl. The aqueous layer was extracted with EtOAc. The organic layers were dried over MgSO4, filtered, and concentrated under reduced pressure to give (R)-2-(ethoxycarbonylamino)-2-phenylacetic acid 41 as a white solid in 82% yield. MS (ESI, EI+) m/z=224.2 (MH+).

출처