반응 #1896381

반응 방정식

4-Aminomethyl-benzenesulfonamide hydrochloride

3,6,8-Tribromo-imidazo[1,2-a]pyrazine

DIPEA

→

4-[(3,6-Dibromo-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulfonamide

수율 76.0%

용매

iBuOH

반응 조건

후처리

1. 1
   온도to cool to room temperature
2. 2
   기타The precipitate formed
3. 3
   여과was filtered
4. 4
   세척washed with diethyl ether

실험 절차

4-Aminomethyl-benzenesulfonamide hydrochloride (2.22 g, 10 mmol) was added to a solution of 3,6,8-Tribromo-imidazo[1,2-a]pyrazine (2.77 g, 10 mmol) and DIPEA (3.65 ml, 21 mmol) in iBuOH (20 mL). The reaction was stirred at 108° C. for 3 h then allowed to cool to room temperature. The precipitate formed was filtered and washed with diethyl ether to give 4-[(3,6-Dibromo-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulfonamide as a pale brown solid (3.5 g, 76% yield). LC-MS m/z 462 [M+H]+.

출처