반응 #1891549

반응 방정식

[4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

5,5-dimethyloxazolin-2-one

→

title compound

수율 50.6%

3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-(1,1-dioxoisothiazolidin-2-yl)phenyl}-5,5-dimethyloxazolidin-2-one

수율 50.6%

반응 조건

후처리

1. 1
   기타By reaction and treatment in the same manner as in Example 110
2. 2
   기타described in Preparation Example 43

실험 절차

By reaction and treatment in the same manner as in Example 110 and using [4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (779 mg) described in Preparation Example 179 and 5,5-dimethyloxazolin-2-one (207 mg) described in Preparation Example 43, the title compound (420 mg) was obtained.

출처