반응 #1890659
ord-bba9a700e57949dc9f1f2cb9147dcad2
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도with heating
- 2기타A solid was formed as the solution
- 3온도cooled
- 4여과The solid was filtered from the remaining solvent
- 5기타dried in the air
실험 절차
As a demonstrative example, a cocrystal comprising a neutral API is described in this example. Cocrystals of nabumetone (a neutral API) and 2,3-naphthalenediol were prepared as follows. A 4.01 g sample of 2,3-naphthalenediol and 5.7 g of nabumetone were dissolved in 50 mL of nitromethane with heating. A solid was formed as the solution cooled and was allowed to stand overnight. The solid was filtered from the remaining solvent and dried in the air to yield 6.61 g (68%) of nabumetone:2,3-naphthalenediol (1:1) cocrystal.