반응 #1889

반응 방정식

2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol

trifluoroacetic acid

sodium hydrogen carbonate

→

crystal

수율 95.7%

5-chloro-α-(2-chlorophenyl)-2-(trifluoroacetylamino)benzyl alcohol

수율 95.7%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   기타After reaction
2. 2
   기타the organic layer was dried
3. 3
   기타after which the solvent was removed
4. 4
   기타the residue was recrystallized from hexane

실험 절차

To a solution of 1.0 g of 2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol in 12 ml of dichloromethane, a solution of 0.8 g of anhydrous trifluoroacetic acid in 2 ml of dichloromethane was added. After reaction, an aqueous solution of sodium hydrogen carbonate was added, and the organic layer was dried, after which the solvent was removed and the residue was recrystallized from hexane to yield 1.3 g of a crystal.

출처