반응 #1887

반응 방정식

sodium cyanoborohydride

2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol

trimethylacetaldehyde

acetic acid

→

crystal

5-chloro-α-(2,4,6-trimethoxyphenyl)-2-(neopentylamino)benzyl alcohol

용매

ethanol

반응 조건

후처리

1. 1
   농축After concentration and subsequent dilution with water
2. 2
   추출the solution was extracted with ethyl acetate
3. 3
   기타After solvent removal

실험 절차

After a solution of 2.5 g of 2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol, 1.01 ml of trimethylacetaldehyde and 0.56 g of acetic acid in 30 ml of ethanol was stirred at room temperature for 1.5 hours, 0.81 g of sodium cyanoborohydride was added, followed by stirring overnight. After concentration and subsequent dilution with water, the solution was extracted with ethyl acetate. After solvent removal, the residue was subjected to silica gel column chromatography to yield 2.2 g of a crystal.

출처