반응 #1886582

반응 방정식

Ethyl 1-(4-bromophenyl)-5-cyclopropyl-pyrazole-4-carboxylate

Intermediate #31

Ethyl 1-(4-bromophenyl)-5-cyclopropyl-pyrazole-4-carboxylate

sodium hydroxide

→

1-(4-bromophenyl)-5-cyclopropyl-pyrazole-4-carboxylic acid

용매

methanol

반응 조건

후처리

1. 1
   기타the methanol was removed by evaporation under reduced pressure
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water (50 mL)
3. 3
   추출extracted with EtOAc (3×25 mL)
4. 4
   세척The combined extracts were washed with water and brine
5. 5
   건조dried (MgSO4)
6. 6
   기타evaporated

실험 절차

Ethyl 1-(4-bromophenyl)-5-cyclopropyl-pyrazole-4-carboxylate (Intermediate #31) (423 mg, 1.29 mmol) was dissolved in methanol (20 mL) and treated with 2M aqueous sodium hydroxide solution (3.23 mL, 6.46 mmol). The mixture was stirred at ambient temperature for 24 h and then the methanol was removed by evaporation under reduced pressure. The residue was dissolved in water (50 mL), acidified to pH4 with 2M HCl and extracted with EtOAc (3×25 mL). The combined extracts were washed with water and brine, dried (MgSO4) and evaporated to leave 1-(4-bromophenyl)-5-cyclopropyl-pyrazole-4-carboxylic acid a white solid. (343 mg, 87%).

출처