반응 #1886

반응 방정식

water

2-amino-5-chloro-2',4',6'-trimethoxybenzophenone

lithium aluminum hydride

→

crystal

수율 96.1%

2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol

수율 96.1%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   추출the solution was extracted with ethyl acetate
2. 2
   건조dried over anhydrous sodium sulfate
3. 3
   기타after which the solvent was removed

실험 절차

To a solution of 3.0 g of 2-amino-5-chloro-2',4',6'-trimethoxybenzophenone in 50 ml of tetrahydrofuran, 0.43 g of lithium aluminum hydride was added, followed by stirring for 1 hour. After water was added, the solution was extracted with ethyl acetate and dried over anhydrous sodium sulfate, after which the solvent was removed and the residue was subjected to silica gel column chromatography to yield 2.9 g of a crystal.

출처