반응 #1885062

반응 방정식

Fmoc-Dap-Z

diethylamine

→

Dap-Z

용매

CH2Cl2

반응 조건

후처리

1. 1
   농축the mixture is concentrated (bath temp. <30° C.)
2. 2
   농축concentrated
3. 3
   workup.ADDITIONTo the residue is added MeOH (20 mL) and CH2Cl2 (300 mL)
4. 4
   농축the solution is concentrated
5. 5
   농축toluene (400 mL), concentrated
6. 6
   workup.WAITthe residue left under vacuum overnight
7. 7
   기타to give product

실험 절차

A 1-L round bottom flask is charged with Fmoc-Dap-Z, CH2Cl2 (122 mL) and diethylamine (61 mL, Acros). The solution is stirred at room temperature and the completion monitored by HPLC. After 7 hours, the mixture is concentrated (bath temp. <30° C.). The residue is suspended in CH2Cl2 (300 mL) and concentrated. This is repeated twice. To the residue is added MeOH (20 mL) and CH2Cl2 (300 mL), and the solution is concentrated. The residue is suspended in CH2Cl2 (100 mL) and toluene (400 mL), concentrated, and the residue left under vacuum overnight to give product.

출처