반응 #1885

반응 방정식

2-acetylamino-5-chloro-2',4',6'-trimethoxybenzophenone

hydrochloric acid

→

crystal

수율 90.2%

2-amino-5-chloro-2',4',-6'-trimethoxybenzophenone

수율 90.2%

용매

ethanol

반응 조건

후처리

1. 1
   온도was refluxed for 1 hour
2. 2
   온도while heating
3. 3
   workup.DISTILLATIONAfter the solvent was distilled off
4. 4
   추출extracted with ethyl acetate
5. 5
   세척After the extract was washed with water
6. 6
   기타dried
7. 7
   기타the solvent was removed

실험 절차

A mixture of 4.7 g of 2-acetylamino-5-chloro-2',4',6'-trimethoxybenzophenone, 50 ml of 6N hydrochloric acid and 50 ml of ethanol was refluxed for 1 hour while heating. After the solvent was distilled off, the residue was basefied with an aqueous solution of sodium hydrogen carbonate and then extracted with ethyl acetate. After the extract was washed with water and dried, the solvent was removed, and the residue was subjected to silica gel column chromatography to yield 3.75 g of a crystal.

출처