반응 #1884991

반응 방정식

ammonium chloride

2,4-dichloropyrimidine

phenylzinc bromide

→

2-chloro-4-phenyl-pyrimidine

용매

THF

THF

반응 조건

후처리

1. 1
   추출extracted with EtOAc twice
2. 2
   세척washed with water
3. 3
   건조dried (MgSO4)
4. 4
   기타Evaporation of solvent
5. 5
   기타gave a yellow residue which
6. 6
   기타was purified by Prep

실험 절차

To a solution of 2,4-dichloropyrimidine (149 mg, 1 mmol) in THF (5 mL), tetrakis(triphenylphosphine) palladium (23 mg, 2 mol %) and 0.5M solution of phenylzinc bromide (2.1 mL, 1.05 mmol) in THF were added. The reaction mixture was stirred at 50° C. for overnight. Then it was added saturated ammonium chloride solution and extracted with EtOAc twice. The organic layers were combined, washed with water and dried (MgSO4). Evaporation of solvent gave a yellow residue which was purified by Prep. HPLC to afford a yellowish oil as 2-chloro-4-phenyl-pyrimidine.

출처