반응 #1882130

반응 방정식

N,N-diisopropylethylamine

1-(2-nitro-benzenesulfonyl)-piperazin-2-one HCl salt

(thymin-1-yl)-acetic acid

PyBOP

→

titled compound

수율 95.0%

1-(2-Nitro-benzenesulfonyl)-4-[(thymin-1-yl)-acetyl]-piperazin-2-one

수율 95.0%

용매

ethyl alcohol

DMF

반응 조건

후처리

1. 1
   기타at room temperature
2. 2
   기타to precipitate solid
3. 3
   여과The solid was filtered off
4. 4
   세척washed with ethanol and ethyl ether
5. 5
   기타dried in vacuo

실험 절차

To a mixture of 1-(2-nitro-benzenesulfonyl)-piperazin-2-one HCl salt (1.13 g, 3.5 mmol), (thymin-1-yl)-acetic acid (0.64 g, 3.5 mmol), and PyBOP (2.00 g, 3.85 mmol) in DMF (11 mL) was addeed N,N-diisopropylethylamine (0.91 mL) at room temperature. After stirring for additional 2 h, the reaction mixture was slowly added to a solution of aqueous ethyl alcohol to precipitate solid. The solid was filtered off, washed with ethanol and ethyl ether, and dried in vacuo to give the titled compound (1.50 g, 95%).

출처