반응 #1880655

반응 방정식

potassium carbonate

cyclohexylamine

4-(2-naphthyloxy)1-chlorobutane

→

N-cyclohexyl-[3-(naphthalen-2-yloxy)-butyl]amine

용매

DMSO

water

반응 조건

후처리

1. 1
   기타Reaction mixture
2. 2
   기타Reaction mixture
3. 3
   추출extracted with ethyl acetate thrice
4. 4
   기타The organic layer was separated
5. 5
   농축concentrated
6. 6
   기타to get oily compound which
7. 7
   기타was later crystallized by benzene hexane

실험 절차

A mixture of anhydrous potassium carbonate (10 gm, in excess) and cyclohexylamine (0.28 ml, 0.003 mole) was taken in dry DMSO (40 ml). Now 4-(2-naphthyloxy)1-chlorobutane (0.5 gm, 0.002 mole) was added in it. Reaction mixture was refluxed at 150° C. for 5 hrs and the reaction was completed as checked by TLC. Reaction mixture was poured in distilled water (60 ml) and extracted with ethyl acetate thrice. The organic layer was separated and concentrated to get oily compound which was later crystallized by benzene hexane to get N-cyclohexyl-[3-(naphthalen-2-yloxy)-butyl]amine, solid. m.p., 94° C., (yield 0.61 gm, 92%).

출처