반응 #1876818

반응 방정식

Phosphorus oxychloride

2-hydroxy-4-phenylquinoline

→

2-chloro-4-phenylquinoline

반응 조건

후처리

1. 1
   온도the mixture was heated
2. 2
   온도to reflux for 4 hours
3. 3
   workup.ADDITIONthe mixture was added slowly
4. 4
   추출The mixture was extracted with methylene chloride
5. 5
   건조dried with magnesium sulfate
6. 6
   여과filtered
7. 7
   농축concentrated

실험 절차

Phosphorus oxychloride (37.4 mL, 402 mmol) was added to 2-hydroxy-4-phenylquinoline and the mixture was heated to reflux for 4 hours. Upon cooling to room temperature, the mixture was added slowly to stirring ice water yielding a white precipitate. The mixture was extracted with methylene chloride, and the organic phases were combined, dried with magnesium sulfate, filtered and concentrated to yield 2-chloro-4-phenylquinoline.

출처