반응 #1876815

반응 방정식

Boron tribromide

Compound ( e )

4-ethoxy-2-trifluoromethylphenol

→

Compound ( g )

수율 63.2%

2-trifluoromethylhydroquinone

수율 63.2%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   workup.ADDITIONwas slowly added dropwise at the same temperature
2. 2
   추출the aqueous layer was extracted with ether
3. 3
   세척washed with saturated aqueous sodium chloride
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

실험 절차

Boron tribromide (11.8 g) was slowly added dropwise to dichloromethane (41 mL) cooled to −78° C., and then Compound (e) (6.47 g) dissolved in dichloromethane (60 mL) was slowly added dropwise at the same temperature and the mixture was stirred at room temperature for 2 hours. The reaction mixture was then poured into ice water and the aqueous layer was extracted with ether. The organic layers were combined, washed with saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 3.53 g of Compound (g).

출처