반응 #1876812

반응 방정식

Bromine

Compound ( b )

3-ethoxybenzotrifluoride

Water

→

Compound ( c )

수율 76.9%

2-bromo-5-ethoxybenzotrifluoride

수율 76.9%

용매

ether

반응 조건

후처리

1. 1
   추출the aqueous layer was extracted three times with ether
2. 2
   세척washed with saturated aqueous sodium bicarbonate and water
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

실험 절차

Bromine (18.2 g) was slowly added dropwise to Compound (b) (19.3 g) at room temperature, and then the mixture was stirred at room temperature for 1 hour. Water and ether were added for liquid separation, and the aqueous layer was extracted three times with ether. The organic layers were combined, washed with saturated aqueous sodium bicarbonate and water, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 21.0 g of Compound (c).

출처