반응 #1876811

반응 방정식

Potassium carbonate

methyl ethyl ketone

ethyl iodide

MEK

3-trifluoromethylphenol

→

Compound ( b )

3-ethoxybenzotrifluoride

용매

water

반응 조건

후처리

1. 1
   온도the reaction mixture was heated
2. 2
   기타to room temperature
3. 3
   추출the aqueous layer was extracted three times with diethyl ether
4. 4
   세척washed with an 1 M aqueous sodium hydroxide solution
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

실험 절차

Potassium carbonate (22.6 g) and then a mixture of methyl ethyl ketone (MEK) (150 mL) and ethyl iodide (47.8 g) were added to a mixture of MEK (310 mL) and 3-trifluoromethylphenol (a) (25.0 g) at room temperature, and the reaction mixture was heated and stirred for 2 hours. After returning the mixture to room temperature, water was added for liquid separation and the aqueous layer was extracted three times with diethyl ether. The organic layers were combined, washed with an 1 M aqueous sodium hydroxide solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 19.3 g of Compound (b).

출처