반응 #1875690

반응 방정식

KOH

1-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-ethanone

Compound 354

2-[2-(5-Bromo-2-hydroxy-phenyl)-quinolin-6-yl]-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid

→

title compound

수율 49.0%

2-{2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-quinolin-6-yl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid

수율 49.0%

용매

ethanol

ethanol

반응 조건

실험 절차

Following the procedure and workup for Compound 354, Compound 354e (100 mg, 0.256 mmol) was reacted with 1-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-ethanone (0.256 mmol) in ethanol (2 mL) using 10% w/v KOH in ethanol (506 μL, 0.64 mmol) to produce the title compound (75 mg, 49% yield). MS: 608.17 (M+H+); HPLC Procedure B, retention time=8.44 min.

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