반응 #1875663

반응 방정식

KOH

1-(2-amino-4-methyl-thiazol-5-yl)-ethanone

Compound 354

2-[2-(5-Bromo-2-hydroxy-phenyl)-quinolin-6-yl]-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid

→

title compound

수율 9.0%

2-(2-amino-4-methyl-thiazol-5-yl)-quinolin-6-yl-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid

수율 9.0%

용매

ethanol

ethanol

반응 조건

실험 절차

Following the procedure and workup for Compound 354, Compound 354e (100 mg, 0.256 mmol) was reacted with 1-(2-amino-4-methyl-thiazol-5-yl)-ethanone (0.256 mmol) in ethanol (2 mL) using 10% w/v KOH in ethanol (506 μL, 0.64 mmol) to produce the title compound (8 mg, 9% yield). MS: 484.19 (M+H+); HPLC Procedure A, retention time=8.57 min.

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