반응 #1872609

반응 방정식

[2-(3-bromo-phenyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

benzophenone imine

sodium tert-butoxide

bis(diphenylphosphino)-1,1′-binaphthyl

→

{2-[3-(Benzhydrylidene-amino)-phenyl]-1-methyl-ethyl}-carbamic acid tert-butyl ester

용매

toluene

ether

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도to reflux for 3 h
3. 3
   기타Reaction
4. 4
   세척organics washed with water and saturated sodium chloride
5. 5
   기타Product isolated as a viscous yellow oil
6. 6
   기타after purification on silica

실험 절차

A suspension of [2-(3-bromo-phenyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester (750 mg, 2.39 mmol), benzophenone imine (0.44 mL, 2.63 mmol), sodium tert-butoxide (298 mg, 3.1 mmol), bis(diphenylphosphino)-1,1′-binaphthyl (45 mg, 0.07 mmol), palladium acetate (16 mg, 0.07 mmol), and toluene (7.5 mL) was heated to reflux for 3 h while stirring under an atmosphere of nitrogen. Reaction diluted with ether and organics washed with water and saturated sodium chloride. Product isolated as a viscous yellow oil after purification on silica. M+1=415.

출처