반응 #1869200

반응 방정식

5-benzyloxy-2-hydroxymethyl-4-pyrone

Kojic acid

ammonia

Erol

→

5-Benzyloxy-2-hydroxymethyl-1 H-pyridin-4-one

용매

ethanol

반응 조건

후처리

1. 1
   온도to reflux overnight
2. 2
   여과then filtered
3. 3
   세척The resultant solid was washed with ether
4. 4
   기타dried in vacuo (5.9 g)

실험 절차

A mixture of 5-benzyloxy-2-hydroxymethyl-4-pyrone (prepared from Kojic acid by the method of D. Erol, J. Med. Chem., 1994, 29, 893) (9.7 g, 40 mmol), concentrated aqueous (880) ammonia (100 mL), and ethanol (20 mL) was heated to reflux overnight. The mixture was allowed to cool to room temperature then filtered. The resultant solid was washed with ether and dried in vacuo (5.9 g).

출처