반응 #1869194

반응 방정식

2-chloro-8-benzyloxyquinoline

NaOMe

→

oil

수율 92.0%

8-Benzyloxy-2-methoxyquinoline

수율 92.0%

용매

toluene

MeOH

반응 조건

후처리

1. 1
   온도The reaction solution was heated
2. 2
   온도After cooling to room temperature
3. 3
   workup.ADDITIONthe reaction solution was poured onto ice
4. 4
   추출extracted with toluene
5. 5
   건조The combined organic extracts were dried (MgSO4)
6. 6
   농축concentrated in vacuo

실험 절차

The crude 2-chloro-8-benzyloxyquinoline from above was dissolved in toluene (10 mL) and added to a stirred 25 wt % solution of NaOMe in MeOH (50 mL). The reaction solution was heated with stirring overnight at 70° C. After cooling to room temperature, the reaction solution was poured onto ice and extracted with toluene. The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give a colorless oil (6.14 g, 92%). The product was used without further purification.

출처