반응 #1869192

반응 방정식

hydroxypyridine

2-Bromo-5-hydroxy-6-nitropyridine

potassium carbonate

Et2O

→

material

수율 89.0%

Ethyl (6-bromo-2-nitro-pyridin-3-yloxy)acetate

수율 89.0%

용매

acetone

반응 조건

후처리

1. 1
   온도The reaction was heated
2. 2
   온도at reflux for 10 hours
3. 3
   기타The precipitate was removed by suction filtration
4. 4
   농축the filtrate was concentrated in vacuo

실험 절차

The hydroxypyridine (f) (30 g, 0.14 mol) was suspended in acetone (200 ml), and potassium carbonate (39 g, 0.28 mol) was added, followed by ethyl bromoacetate (15.7 ml, 0.14 mmol). The reaction was heated at reflux for 10 hours, then was cooled to room temperature and diluted with Et2O. The precipitate was removed by suction filtration, and the filtrate was concentrated in vacuo to afford material (38 g, 89%), which was used without further purification.

출처