반응 #1869188

반응 방정식

( b )

4-Oxo-1,4-dihydro-quinoline-6-carbonitrile

phosphorous tribromide

→

product

수율 87.0%

4-Bromo-quinoline-6-carbonitrile

수율 87.0%

용매

—

ice water

DMF

water

반응 조건

후처리

1. 1
   여과The product was filtered off
2. 2
   세척washed with water and air
3. 3
   기타dried

실험 절차

To a solution of (b) (12 g, 70.5 mmol) in DMF (75 ml) was added dropwise phosphorous tribromide (8 ml, 84.6 mmol) over five minutes (slightly exothermic). The reaction was allowed to cool to room temperature and was then diluted with ice water (100 ml) and stirred 1 hour then diluted with additional water (300 ml). The product was filtered off, washed with water and air dried to provide 14.3 g of product (87%).

출처