반응 #1869187

반응 방정식

Intermediate ( a )

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-benzonitrile

Dowtherm A

→

gold

수율 94.3%

4-Oxo-1,4-dihydro-quinoline-6-carbonitrile

수율 94.3%

용매

ether

반응 조건

후처리

1. 1
   온도After an additional five minutes at reflux
2. 2
   여과The product was filtered off
3. 3
   세척thoroughly washed with ether
4. 4
   기타air dried

실험 절차

Intermediate (a) (27.5 g, 0.101 mol) was slowly added over five minutes to refluxing Dowtherm A (200 ml). After an additional five minutes at reflux, the mixture was allow to cool to room temperature then ether (200 ml) was added. The product was filtered off, thoroughly washed with ether then air dried to afford the product as a gold coloured solid (16.2 g, 94%).

출처