반응 #1869177

반응 방정식

4-piperidone hydrochloride monohydrate

benzyloxycarbonyl chloride

hydrochloric acid

→

title compound

수율 100.3%

N-benzyloxycarbonyl-4-piperidone

수율 100.3%

용매

sodium hydroxide

—

aqueous solution

반응 조건

후처리

1. 1
   추출the aqueous solution was extracted three times with ethyl acetate
2. 2
   세척The organic layer was washed with a saturated aqueous solution of sodium bicarbonate
3. 3
   건조a saturated aqueous solution of sodium chloride subsequently, dried over anhydrous magnesium sulfate
4. 4
   농축concentrated

실험 절차

A 4-piperidone hydrochloride monohydrate (15.3 g) was dissolved in 2N aqueous solution of sodium hydroxide (100 mL). To the solution was added a benzyloxycarbonyl chloride (20.4 g) at 0° C. The mixture was stirred for 1 hour. The reaction mixture was neutralized with 2N hydrochloric acid, and the aqueous solution was extracted three times with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride subsequently, dried over anhydrous magnesium sulfate and concentrated to give the title compound (23.3 g) having the following physical data.

출처