반응 #1867446

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(4S)-1-[(2S,3S)-3-(N2 -t-butoxycarbonyl-L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl]-4-chloro-N-t-butyl-L-prolinamide

(4S)-1-[(2S,3S)-3-(N2 -t-Butoxycarbonyl-L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl]-4-chloro-N-t-butyl-L-prolinamide

7-methoxy-2-benzofurancarboxylic acid

→

title compound

수율 65.4%

(4S)-1-{(2S,3S)-3-(N2 -(7-Methoxy-2-benzofurancarbonyl)-L-asparaginyl]amino-2-hydroxy-4-phenylbutyryl}-4-chloro-N-t-butyl-L-prolinamide

수율 65.4%

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실험 절차

Following a procedure similar to that described in Example 16, but using 155 mg (0.26 mmol) of (4S)-1-[(2S,3S)-3-(N2 -t-butoxycarbonyl-L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl]-4-chloro-N-t-butyl-L-prolinamide (prepared as described in Example 65) and 50 mg (0.26 mmol) of 7-methoxy-2-benzofurancarboxylic acid, 114 mg of the title compound were obtained as a colorless powder, melting at 125°-136° C.

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