반응 #1866769

반응 방정식

methanol

(S)-(+)-4-(oxiranylmethoxy)-1H-indole

4-(phenoxy)piperidine

oxalic acid

→

title compound

(2S)-(-)-1-(4-indolyloxy)-3-(4-phenoxypiperidin-1-yl)-2-propanol ethanedioate

용매

ethyl acetate

ethyl acetate

반응 조건

실험 절차

The title compound was prepared in similar fashion from (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 4-(phenoxy)piperidine. The resulting free base was dissolved in ethyl acetate, and precipitated with one equivalent of oxalic acid in ethyl acetate in 69% overall yield. FDMS m/e=366 (M+ of free base). α[D]589 =-14.29 (c=0.5, methanol).

출처