반응 #1866530

반응 방정식

3,4,4-trifluoro-3-buten-1-ol

Jones reagent

→

3,4,4-trifluoro-3-butenoic

3,4,4-trifluoro-3-butenoic acid

용매

acetone

반응 조건

후처리

1. 1
   기타are at a temperature of about 51°-54° C

실험 절차

The first method involves hydrolysis of 4-bromo-1,1,2-trifluoro-1-butene (H) with water in the presence of N-methyl pyrrolidinone to give 3,4,4-trifluoro-3-buten-1-ol (III), followed by Jones oxidation under conditions not previously known. These conditions are at a temperature of about 51°-54° C. In addition, the 3,4,4-trifluoro-3-buten-1-ol in acetone solvent and the Jones reagent are added to the reaction vessel simultaneously to afford 3,4,4-trifluoro-3-butenoic (IV) add in 52% overall yield. ##STR4## Method 2, Scheme 1, Compound IV

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