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glucose

serotonin

bilirubin

Glucose

→

dopamine

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후처리

1. 1
   workup.ADDITIONtreat diseases or disorders
2. 2
   workup.ADDITIONExemplary Pancreatic Developmental gene mediated diseases and disorders which can be treated with cell/tissues
3. 3
   기타obtained
4. 4
   온도reflux etc.), a disease or disorder of the stomach and/or duodenum (e.g., functional dyspepsia, inflammation of the gastric mucosa, gastritis, stress gastritis, chronic erosive gastritis, atrophy of gastric glands, metaplasia of gastric tissues, gastric ulcers, duodenal ulcers
5. 5
   workup.ADDITIONallergic rhinitis or conjunctivitis, angioedema of the lids, hereditary angioedema, antireceptor hypersensitivity reactions and autoimmune diseases, Hashimoto's thyroiditis, systemic lupus erythematosus, Goodpasture's syndrome, pemphigus, myasthenia gravis, Grave's and Raynaud's disease, type B insulin-resistant diabetes, rheumatoid arthritis, psoriasis, Crohn's disease, scleroderma, mixed connective tissue disease, polymyositis, sarcoidosis, glomerulonephritis

실험 절차

In some embodiments, antisense oligonucleotides are used to prevent or treat diseases or disorders associated with Pancreatic Developmental gene family members. Exemplary Pancreatic Developmental gene mediated diseases and disorders which can be treated with cell/tissues regenerated from stem cells obtained using the antisense compounds comprise: a disease or disorder associated with abnormal function and/or expression of a Pancreatic Developmental gene, a disease or disorder associated with abnormal function and/or expression of any of the genes listed in Table 1, a cardiovascular disease or disorder (e.g., congestive heart failure, myocardial infarction, an Ischemic disease, an atrial or ventricular arrhythmia, a hypertensive vascular disease, a peripheral vascular disease, and atherosclerosis etc.), inflammation, a gastrointestinal disease or disorder (e.g., a disorder of the esophagus, achalasia, vigoruos achalasia, dysphagia, cricopharyngeal incoordination, pre-esophageal dysphagia, diffuse esophageal spasm, globus sensation, Barrett's metaplasia, gastroesophageal reflux etc.), a disease or disorder of the stomach and/or duodenum (e.g., functional dyspepsia, inflammation of the gastric mucosa, gastritis, stress gastritis, chronic erosive gastritis, atrophy of gastric glands, metaplasia of gastric tissues, gastric ulcers, duodenal ulcers, a neoplasm of the stomach), a disease or disorder of the pancreas (e.g., acute or chronic pancreatitis, insufficiency of the exocrinic or endocrinic tissues of the pancreas like steatorrhea, diabetes etc.), a neoplasm of the exocrine or endocrine pancreas (e.g., multiple endocrine neoplasia syndrome, ductal adenocarcinoma, cystadenocarcinoma, an islet cell tumor, insulinoma, gastrinoma, carcinoid tumors, glucagonoma, Zollinger-Ellison syndrome, Vipoma syndrome, malabsorption syndrome etc.), a disease or disorder of the bowel (e.g., chronic inflammatory disease of the bowel, Crohn's disease, ileus, diarrhea and constipation, colonic inertia, megacolon, malabsorption syndrome, ulcerative colitis, a functional bowel disorder, irritable bowel syndrome etc.), a neoplasm of the bowel (e.g., familial polyposis, adenocarcinoma, primary malignant lymphoma, carcinoid tumors, Kaposi's sarcoma, polyps, cancer of the colon and rectum); a hepatic disease or disorder (e.g., bilirubin metabolism disorder, jaundice, syndroms of Gilbert's, Crigler-Najjar, Dubin-Johnson and Rotor; intrahepatic cholestasis, hepatomegaly, portal hypertension, ascites, Budd-Chiari syndrome, portal-systemic encephalopathy, fatty liver, psittacosis, Reye's syndrome, a liver disease due to alcohol, alcoholic hepatitis or cirrhosis, fibrosis, cirrhosis etc.), fibrosis and/or cirrhosis of the liver due to inborn errors of metabolism or exogenous substances, a storage disease or disorder, syndrome of Gauche's, Zellweger's, Wilson's-disease, acute or chronic hepatitis, viral hepatitis and its variants; an inflammatory condition of the liver due to virus, bacteria, fungi, protozoa, helminth; a drug induced disease or disorder of the liver, a chronic liver disease like primary sclerosing cholangitis, alphai-antitrypsin-deficiency, primary biliary cirrhosis, a postoperative liver disorder like postoperative intrahepatic cholestasis, a hepatic granuloma, a vascular liver disease or disorder associated with systemic disease, a benign or malignant neoplasm of the liver, a disturbance of liver metabolism in the new-born or prematurely born, a musculoskeletal Disease (e.g., osteoporosis, postmenopausal osteoporosis, senile osteoporosis, secondary osteoporosis, idiopathic juvenile osteoporosis, Paget's disease of the bone, osteochondroma, osteocartilaginous exostose, etc.), a tumor of the bone (e.g., benign chondromas, chondroblastoma, chondromyxoid fibromas, osteoid osteomas, a giant cell tumor of the bone, multiple myeloma, osteosarcoma (osteogenic sarcoma), fibrosarcoma, malignant fibrous histiocytoma, chondrosarcoma, Ewing's tumor (Ewing's sarcoma), malignant lymphoma of bone (reticulum cell sarcoma, metastatic tumors of the bone), osteoarthritis, and gout and Pseudogout; a disorder of joint and connective tissue (e.g., rheumatoid arthritis, psoriatic arthritis, discoid lupus erythematosus, systemic lupus erythamatosus, scleroderma (systemic sclerosis), Sjogren's syndrome, connective tissue disease, polymyositis and dermatomyositis, relapsing polychondritis, vasculitis, polyarteritis nodosa, polymyalgia rheumatica, temporal arteritis, Wegener's granulomatosis, Reiter's syndrome, Behcet's syndrome, ankylosing spondylitis, or Charcot's joints (neuropathic joint disease) etc.); a bone and joint infection (e.g., osteomyelitis, and infectious arthritis); a disease or disorder of muscles, bursas, and/or tendons (e.g., spasmodic torticollis, fibromyalgia syndromes (myofascial pain syndromes, fibromyositis), bursitis, tendinitis and tenosynovitis), foot problem (e.g., ankle sprain, foot fractures, heel spurs, Sever's disease, posterior achilles tendon bursitis, anterior achilles tendon bursitis, posterior tibial neuralgia, pain in the ball of the foot (caused by damage to the nerves between the toes or to the joints between the toes and foot), onychomycosis, or nail discoloration), cancer, an inflammatory disease or disorder such as: hypersensitivity reactions of type I-IV (e.g., a hypersensitivity disease of the lung including asthma, atopic diseases, allergic rhinitis or conjunctivitis, angioedema of the lids, hereditary angioedema, antireceptor hypersensitivity reactions and autoimmune diseases, Hashimoto's thyroiditis, systemic lupus erythematosus, Goodpasture's syndrome, pemphigus, myasthenia gravis, Grave's and Raynaud's disease, type B insulin-resistant diabetes, rheumatoid arthritis, psoriasis, Crohn's disease, scleroderma, mixed connective tissue disease, polymyositis, sarcoidosis, glomerulonephritis, acute or chronic host versus graft reactions); a pulmonary disease or disorder such as: Chronic obstructive pulmonary disease (COPD); a urinary system disorder such as: malign disorders of the organs constituting the genitourinary system of female and male, a renal disease or disorder like acute or chronic renal failure, immunologically mediated renal diseases like renal transplant rejection, lupus nephritis, immune complex renal diseases, glomerulopathies, nephritis, toxic nephropathy, an obstructive uropathy like benign prostatic hyperplasia (BPH), neurogenic bladder syndrome, urinary incontinence like urge-, stress-, or overflow incontinence, pelvic pain, and erectile dysfunction, a disease or a disorder associated with defective endocrine pancreatic development (e.g., type 2 diabetes mellitus); a disease or a disorder associated with defective neurogenesis; a neurodegenerative disease or disorder (e.g. Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis etc.); a disease or a disorder associated with defective development of the vestibular and/or auditory system, a disease or a disorder associated with photoreceptor cell degeneration (e.g., loss of vision, age-related macular degeneration etc.), obesity, a disease or a disorder associated with defective functioning of liver (e.g., liver failure), pulverulent cataract, cerulean cataract, non-syndromic congenital cataract, congenital cataract-microcornea syndrome, a pancreatic disease or a disorder (e.g., diabetes, MODY syndrome, Partial pancreas agenesis, chronic hyperglycemia, pancreatic beta cell failure, glucose toxicity, Glucose Intolerance, Metabolic syndrome X etc.), Crohn's disease, myocardial infarction, hypercholesteremia, intercranial arterosclerosis, cerebral infarction, herpesviral infection, a disease or disorder associated with impaired lipid metabolism, a disease or disorder associated with insulin production, a disease or disorder associated with scrotonin production (e.g., depression and obesity), a neurological disease or disorder (including disorders associated with neural defects (e.g., defects in motor neurons, serotonin-producing neurons, dopamine neurons, and developmental defects in the forebrain, midbrain, hindbrain, and spinal cord) etc.), a disease of the reproductive System and a metabolic disease or disorder such as diabetes (e.g., type 2 diabetes: non-insulin dependent diabetes mellitus).

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