반응 #1862136

반응 방정식

5-bromo-1H-pyrazolo[3,4-c]pyridine

NIS

water

→

5-bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine

용매

DMF

반응 조건

후처리

1. 1
   여과then filtered
2. 2
   세척The solid was washed with water and 5% Na2S2O5
3. 3
   건조The crude product was dried under high vacuum overnight

실험 절차

A solution containing 5-bromo-1H-pyrazolo[3,4-c]pyridine (168.0 g, 848.4 mmol) and NIS (286.3 g, 1.27 mol) in DMF (1.2 L) was stirred on at room temperature. The reaction mixture was poured into water then filtered. The solid was washed with water and 5% Na2S2O5. The crude product was dried under high vacuum overnight to give 5-bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine.

출처