반응 #1860835

반응 방정식

DMF

N-cyclopropyl-4-[6-(3-fluorophenoxy)-8-(methylsulfanyl)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide

oxone

oxone

→

crude product

수율 93.0%

N-cyclopropyl-4-[6-(3-fluorophenoxy)-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide

수율 93.0%

반응 조건

후처리

1. 1
   기타After reaction for 72 h
2. 2
   추출Extraction
3. 3
   여과with ethyl acetate/water, filtration of the organic phase through a Whatman
4. 4
   여과filter
5. 5
   기타evaporation of the organic phase

실험 절차

To a stirred solution of 4.96 g (11.06 mmol) N-cyclopropyl-4-[6-(3-fluorophenoxy)-8-(methylsulfanyl)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide which was prepared according to intermediate example 486b in DMF (250 mL) were added 20.4 g (33.18 mmol) oxone in one portion at rt. After reaction for 72 h, further 30 g (55 mmol) oxone are added and the mixture is heated at 70° C. for one hour. Extraction with ethyl acetate/water, filtration of the organic phase through a Whatman filter and evaporation of the organic phase yielded the crude product (4.96 g, 93%) which was used without further purification.

출처