반응 #1859588

반응 방정식

compound 20

4-([1,1′-Biphenyl]-2-yl)-2-((1-methylcyclohexyl)methylene)-2,3-dihydro-1H-inden-1-one

→

crude compound 21

수율 88.2%

4-([1,1′-Biphenyl]-2-yl)-2-((1-methylcyclohexyl)methyl)-2,3-dihydro-1H-inden-1-one

수율 88.2%

용매

ethanol

water

반응 조건

후처리

1. 1
   기타at room temperature
2. 2
   기타overnight
3. 3
   여과The mixture was filtered through Celite
4. 4
   세척the filter cake was washed with ethanol (200 mL)
5. 5
   농축The filtrate was concentrated under reduced pressure

실험 절차

A mixture of Raney nickel (a slurry in water, 4.4 g), compound 20 (4.4 g, 11.21 mmol, 1 equiv) in ethanol (450 mL) was hydrogenated @ 50 psi at room temperature overnight. The mixture was filtered through Celite and the filter cake was washed with ethanol (200 mL). The filtrate was concentrated under reduced pressure to give crude compound 21 (3.9 g, 88% yield) as a pale-yellow oil. This material was used subsequently.

출처