반응 #1859583

반응 방정식

compound 12

4-(3,5-Di-tert-butylphenyl)-2-((1-methylcyclohexyl)methylene)-2,3-dihydro-1H-inden-1-one

→

crude compound 13

수율 80.0%

4-(3,5-Di-tert-butylphenyl)-2-((1-methylcyclohexyl)methyl)-2,3-dihydro-1H-inden-1-one

수율 80.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타at room temperature
2. 2
   기타for 4 hours
3. 3
   여과The mixture was filtered through Celite
4. 4
   세척the filter cake was washed with ethanol (500 mL)
5. 5
   농축The filtrate was concentrated under reduced pressure

실험 절차

A mixture of Raney nickel (slurry in water, 12.5 g), compound 12 (12.5 g, 29.16 mmol, 1 equiv) and ethanol (1000 mL) was hydrogenated @ 50 psi at room temperature for 4 hours. The mixture was filtered through Celite and the filter cake was washed with ethanol (500 mL). The filtrate was concentrated under reduced pressure to give crude compound 13 (10.0 g, 80% yield) as a pale-yellow oil. This material was used subsequently.

출처