반응 #1857562

반응 방정식

tert-butyl ((3S,7S,8S,9S)-8-isopentyl-9-methyl-2-oxo-7-propoxyoxonan-3-yl)carbamate

HCl

dioxane

→

(3S,7S,8S,9S)-8-isopentyl-9-methyl-2-oxo-7-propoxyoxonan-3-aminium chloride

용매

DCM

반응 조건

후처리

1. 1
   기타The solvent was removed under a stream of N2, which
2. 2
   기타afforded a white solid
3. 3
   기타This solid was triturated with Et2O (3×3 mL)
4. 4
   기타the resulting powder was dried under high vacuum for 1 h

실험 절차

To a solution of tert-butyl ((3S,7S,8S,9S)-8-isopentyl-9-methyl-2-oxo-7-propoxyoxonan-3-yl)carbamate (330 mg, 0.826 mmol) in DCM (3 mL) was added a solution of HCl in dioxane (2.07 mL, 8.26 mmol, 4M) under N2 and the resulting solution was stirred at room temperature for 2 h. The solvent was removed under a stream of N2, which afforded a white solid. This solid was triturated with Et2O (3×3 mL) and the resulting powder was dried under high vacuum for 1 h to give (3S,7S,8S,9S)-8-isopentyl-9-methyl-2-oxo-7-propoxyoxonan-3-aminium chloride (59): ESIMS m/z 300 ([M+H]+).

출처