반응 #1851985

반응 방정식

3-(3-chloropropyl)-1,2-benzisoxazole

(6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline

NH3

→

title compound

(6bR,10aS)-8-[3-(1,2-benzisoxazol-3-yl)propyl]-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline hydrochloride

반응 조건

실험 절차

The title compound was prepared from addition 3-(3-chloropropyl)-1,2-benzisoxazole from Step D Example 22 and (6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline following the General procedure A of Example 197. 1H NMR (300 MHz, CDCl3) δ 7.59-7.62 (m, 1H), 7.46-7.50 (m, 2H), 7.20-7.25 (m, 1H), 6.57 (dd, J=7.7 Hz, 7.3 Hz, 1H), 6.43 (d, J=6.9 Hz, 1H), 6.33 (d, J=7.3 Hz), 3.48-3.52 (m, 1H), 3.06-3.25 (m, 4H), 2.94-2.99 (m, 2H), 2.70-2.89 (m, 4H), 2.79 (s, 3H), 2.20-2.65 (m, 3H), 1.92-2.07 (m, 4H) ppm. MS (CI, NH3) m/e 389 (base, M+H+).

출처