반응 #1851984

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3-(3-chloropropyl)-6-fluoro-1,2-benzisoxazole

(6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline

NH3

→

title compound

(6bR,10aS)-8-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline hydrochloride

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실험 절차

The title compound was prepared from addition of 3-(3-chloropropyl)-6-fluoro-1,2-benzisoxazole from Step D and (6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline following General procedure A, Example 197. 1H NMR (300 MHz, CDCl3) δ 7.63 (dd, J=8.8 Hz, 4.7 Hz, 1H); 7.20-7.24 (m, 1H), 7.03-7.10 (m, 1H), 6.65 (dd, J=7.7 Hz, 7.7 Hz, 1H), 6.50 (d, J=7.3 Hz, 1H), 6.41 (d, J=7.3 Hz), 3.73-3.77 (m, 1H), 3.55-3.62 (m, 1H), 3.21-3.32 (m, 3H), 2.91-3.10 (m, 3H), 2.86 (s, 3H), 2.75-2.82 (m, 2H), 2.54-2.63 (m, 1H), 2.41-2.48 (m, 1H), 1.95-2.11 (m, 6H) ppm. MS (CI, NH3) m/e 407 (base, M+H+).

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