반응 #1848482
ord-966c14b5a49f4b4dbdd229b59a1c2e83
반응 방정식
thiophene-2-carbonyl chloride
3-(3-aminophenyl)-4-bromo-1-methylpyrazole
triethylamine
→
title compound
수율 73.6%
N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl][2-thienyl]carboxamide
수율 73.6%
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축concentrated
실험 절차
To thiophene-2-carbonyl chloride (11 μL, 0.09 mmol) in CH2Cl2 (1 mL) was added dropwise a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (25 mg. 0.09 mmol) and triethylamine (14 μL, 0.09 mmol) in CH2Cl2 (0.5 mL). The reaction mixture was stirred for 16 h and concentrated. Chromatography on flash silica (50% EtOAc/hexane) gave the title compound as a colourless solid (24 mg, 68%), m.p. 127.8-128.6° C. (EtOAc/hexane).