반응 #1845692

반응 방정식

N-(3-aminopropyl)-N'-(4-cyclohexylphenyl)thiourea

methyliodide

→

2-(4-cyclohexylphenyl)imino-hexahydropyrimidine

용매

amyl alcohol

반응 조건

후처리

1. 1
   온도refluxed for 1 hour
2. 2
   workup.DISTILLATIONAfter distilling off the solvent
3. 3
   세척washed
4. 4
   workup.ADDITIONwith dilute alkaline solution and water
5. 5
   workup.DISTILLATIONThe methylene chloride is distilled off
6. 6
   기타the crude 2-(4-cyclohexylphenyl)imino-hexahydropyrimidine is recrystallised from acetonitrile

실험 절차

A solution of 2.9 g of N-(3-aminopropyl)-N'-(4-cyclohexylphenyl)thiourea and 0.65 ml of methyliodide in 20 ml of amyl alcohol is slowly heated to the boiling point and then refluxed for 1 hour. After distilling off the solvent, the residue is taken up in methylene chloride and washed with dilute alkaline solution and water. The methylene chloride is distilled off and the crude 2-(4-cyclohexylphenyl)imino-hexahydropyrimidine is recrystallised from acetonitrile. The purified product has a melting point of 179°-181° C.

출처