반응 #1834413

반응 방정식

(R)-2-amino-3-(5-bromo-2-fluorophenyl)propan-1-ol

rac-2-chloropropanoyl chloride

3-bromopyridazine hydrobromide

→

title compound

(2R,5R)-5-(2-Fluoro-5-pyridazin-3-yl-benzyl)-2-methyl-morpholine hydrochloride

반응 조건

후처리

1. 1
   기타described for the preparation of B-18

실험 절차

The title compound was prepared from (R)-2-amino-3-(5-bromo-2-fluorophenyl)propan-1-ol (Chiral Quest) and rac-2-chloropropanoyl chloride, in analogy to the sequence of reactions described for the preparation of B-18 substituting 2-bromopyrimidine for 3-bromopyridazine hydrobromide. LC-MS A: tR=0.52 min; [M+H]+=288.25.

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