반응 #1833212

반응 방정식

2,6-dichloro-5-methoxy-4-vinyl pyrimidine

dichloromethane methanol

→

title compound

수율 100.0%

2,6-Dichloro-5-methoxy-pyrimidine-4-carbaldehyde

수율 100.0%

반응 조건

후처리

1. 1
   기타Ozone gas was bubbled
2. 2
   기타The reaction was quenched with dimethyl sulfide (50 mL)
3. 3
   농축concentrated under reduced pressure at 40° C.

실험 절차

A solution of 2,6-dichloro-5-methoxy-4-vinyl pyrimidine (50 g, 0.24 mol) in dichloromethane:methanol (4:1, 2 L) was cooled to −78° C. Ozone gas was bubbled therethrough for 5 h. The reaction was quenched with dimethyl sulfide (50 mL). The mixture was slowly warmed to room temperature and concentrated under reduced pressure at 40° C. to provide the title compound (50.5 g, 100%); high-performance liquid chromatography (HPLC; 85% acetonitrile buffered with 0.1% volume per volume (v/v) acetic acid).

출처