반응 #1826678

반응 방정식

methyl (E)-4-hydroxy-3-methoxycinnamate

6-bromohexanol

potassium carbonate

→

methyl (E)-3-[3-methoxy-4-(6-hydroxyhexyloxy)phenyl]acrylate

용매

2-butanone

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 5 hrs
3. 3
   온도Then, the reaction mixture was cooled
4. 4
   기타partitioned between ethyl acetate and water
5. 5
   건조The organic phase was dried over magnesium sulphate
6. 6
   여과filtered
7. 7
   기타evaporated

실험 절차

A mixture of 0.5 g of methyl (E)-4-hydroxy-3-methoxycinnamate, 10 ml of 2-butanone, 0.35 ml of 6-bromohexanol and 1 g of ground potassium carbonate was heated under reflux for 5 hrs. Then, the reaction mixture was cooled and partitioned between ethyl acetate and water. The organic phase was dried over magnesium sulphate, filtered and evaporated. Chromatography on 100 g of silica gel with toluene/ethyl acetate (1:1) gave 750 ml of methyl (E)-3-[3-methoxy-4-(6-hydroxyhexyloxy)phenyl]acrylate as a colorless solid, λmax. (CH2Cl2): 323 nm (ε=20513).

출처