반응 #1823529

반응 방정식

N,N,N-trimethylbenzenemethanaminium hydroxide

(±)-3,4-dihydro-N-(phenylmethyl)-2H-1-benzopyran-2-methanamine

1,1'-oxybisethane

→

(±)-3-[[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl](phenylmethyl)amino]propanenitrile

수율 28.6%

용매

2-propenenitrile

반응 조건

후처리

1. 1
   온도at reflux temperature
2. 2
   온도the reaction mixture was cooled
3. 3
   여과The whole was filtered over diatomaceous earth
4. 4
   기타the filtrate was evaporated

실험 절차

3 ml of N,N,N-trimethylbenzenemethanaminium hydroxide was added dropwise to a stirred mixture of 60 g (±)-3,4-dihydro-N-(phenylmethyl)-2H-1-benzopyran-2-methanamine in 350 ml of 2-propenenitrile. After stirring for 4 days at reflux temperature, the reaction mixture was cooled and poured into 1,1'-oxybisethane. The whole was filtered over diatomaceous earth and the filtrate was evaporated, yielding 21 g (28.6%) of (±)-3-[[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl](phenylmethyl)amino]propanenitrile as crude residue (interm. 21).

출처