반응 #1818819

반응 방정식

1-oxo-2,3,9,10-tetrahydro-1H-benzo[b]indeno[5,4-f]thiepin-6-carboxylic acid

sodium hydroxide

sodium borohydride

→

(±)-1-Hydroxy-2,3,9,10-tetrahydro-1H-benzo[b]indeno-[5,4-f]thiepin-6-carboxylic acid

용매

water

반응 조건

후처리

1. 1
   workup.STIRRINGthe reaction mixture was stirred at room temperature overnight
2. 2
   기타Careful acidification of the mixture with 10% hydrochloric acid precipitated the racemic title compound which
3. 3
   여과was collected by filtration
4. 4
   세척washed well with water

실험 절차

A suspension of 1-oxo-2,3,9,10-tetrahydro-1H-benzo[b]indeno[5,4-f]thiepin-6-carboxylic acid (3.10 g, 10 mmole) in water (60 ml) was stirred during the addition of 1N sodium hydroxide solution (10 ml). After stirring for 15 minutes the mixture was treated with sodium borohydride (0.95 g, 25 mmole) in portions and the reaction mixture was stirred at room temperature overnight. Careful acidification of the mixture with 10% hydrochloric acid precipitated the racemic title compound which was collected by filtration and washed well with water.

출처