반응 #1810795

반응 방정식

ethyl 3-hydroxybutyrate

ethyl 4-bromo-3-hydroxybutyrate

→

ethyl (R)-4-bromo-3-hydroxybutyrate

수율 99.0%

반응 조건

후처리

1. 1
   기타After reaction for 1 hour 40 minutes

실험 절차

Instead of ethyl 3-hydroxybutyrate used in Example 1, ethyl 4-bromo-3-hydroxybutyrate (1%, w/v) was used as a reactant and novozyme 435 lipase was used as a biocatalyst. After reaction for 1 hour 40 minutes, ethyl (R)-4-bromo-3-hydroxybutyrate (99% e.e) was obtained at 88.3% conversion.

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