반응 #1808098

반응 방정식

propyl N-cyano-5-isopropylamino-3-pyridinecarboximidate

2-(2-chlorophenyl)ethylamine

→

title compound

수율 81.0%

N-cyano-N'-[2-(2-chlorophenyl)ethyl]-5-isopropylamino-3-pyridinecarboximidamide

수율 81.0%

용매

methanol

반응 조건

후처리

1. 1
   농축the reaction mixture was concentrated under reduced pressure
2. 2
   기타the residue obtained
3. 3
   기타was purified by silica gel column chromatography (Wako Gel C-200, 30 g; eluted with chloroform:methanol=100:1)
4. 4
   기타further crystallized from diethyl ether

실험 절차

To a solution of propyl N-cyano-5-isopropylamino-3-pyridinecarboximidate (98 mg, 0.42 mmol) in methanol (3 ml) was added 2-(2-chlorophenyl)ethylamine (79 mg, 0.51 mmol), and the mixture was stirred for 105 minutes. After the reaction was completed, the reaction mixture was concentrated under reduced pressure and the residue obtained was purified by silica gel column chromatography (Wako Gel C-200, 30 g; eluted with chloroform:methanol=100:1) and further crystallized from diethyl ether to give the title compound (110 mg, 0.34 mmol) as colorless crystals in the yield of 80%.

출처